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Source document· June 1, 2026

The S&P 500 just flashed a rare warning signal last seen in dot-com bubble. Crashproof your wealth now

View original at finance.yahoo.com
The S&P 500 just flashed a rare warning signal last seen in dot-com bubble. Crashproof your wealth now Moneywise and Yahoo Finance LLC may earn commission or revenue through links in the content below…
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  • The S&P 500 CAPE ratio has recently climbed to roughly 41.33, a level reached only twice in the past century.

    60% confidence
  • Since 1871, Shiller's CAPE ratio has exceeded 24 on only six occasions, with the first five occurring immediately prior to major market downturns.

    60% confidence
  • Higher CAPE ratios have historically been associated with lower long-term stock market returns.

    60% confidence
  • A market crash or recession is not necessarily imminent despite the elevated CAPE ratio.

    60% confidence
  • The CAPE ratio has not been a reliable indicator of when exactly a market downturn will begin.

    60% confidence
  • A current CAPE ratio of 41.33 means investors are paying roughly $41.33 for every $1 of inflation-adjusted earnings generated over the previous 10 years.

    60% confidence
  • The CAPE ratio is best used as a risk management tool for assessing portfolio diversification rather than as a market-timing tool.

    60% confidence
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Late-2026 Biotech Catalyst Season: FDA Decisions and Pivotal Readouts Converge Across Oncology, Hepatology and Cardiometabolic
Mid-November 2026 is dense with scheduled biotech catalysts. The ivonescimab BLA PDUFA date is 2026-11-14, the lorundrostat PDUFA date is 2026-12-22, and Phase 3 ECLIPSE hepatitis delta data are due in Q1 2027. Alongside these, siRNA and antibody programs (plozasiran, elebsiran/tobevibart, ianalumab, nipocalimab) reported or presented data at AHA, AASLD, ACR and ASH, while Oryzon advanced iadademstat in AML with Spanish trial authorizations and a planned ALICE-3 Phase III. Late-stage data and regulatory milestones are driving the sentiment. A planned delisting (EGM 2026-11-19, application 2027-01-25) is a separate corporate-structure event with no clear link to the rest.
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EPKINLY Regulatory-Clinical Success Cascade
High probability of expanded label indications, additional combination approvals, and competitive positioning strength in follicular lymphoma market. Predicts positive commercial uptake and potential accelerated review for related indications.
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Donde las fuentes discrepan
Ford Motor Company
Both facts give cash for Ford Motor Company at the same point in time (2025-12-31; FY 2025 year-end and Q4 2025 year-end are the same date). Both are labelled USD, but the values are 23,356,000,000 and 23.356, which cannot both be true in USD. The two numbers agree once the second is read as billions (23.356 bn = 23,356,000,000), so the economic content is consistent and the conflict is a unit/scale error in the Q4 2025 record. The period is not the reason for the conflict: a Q4 and an FY figure at the same year-end date should match.
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